Irf7 pdc

WebNational Center for Biotechnology Information WebAug 13, 2024 · IRF7 is a critical regulator of type I IFN production when pathogens are detected by TLR7/9 in pDC. However, hyperactivation of pDC can cause life-threatening autoimmune diseases. To avoid the deleterious effects of aberrant pDC activation, tight regulation of IRF7 is required.

3665 - Gene ResultIRF7 interferon regulatory factor 7 [ (human)]

WebAug 27, 2009 · Type I IFN production by pDCs correlates with differential interferon regulatory factor 7 (IRF7) translocation into the nucleus induced by the 2 TLR7 ligands. Surprisingly, with both activators we nevertheless observed the rapid expression of the IFN-inducible genes mxa, ... Differential pDC maturation is triggered by different TLR7 ligands ... WebSep 5, 2024 · The relative RNA expressions (normalized by actin) of (A) Sting, (C) Irf3, (D) Irf7, (E) Mx1, (F) Ifn-β, (G) Ifn-γ, and (H) Cxcl10 are shown. (B) Isolated splenocytes were analyzed for STING protein expression by western blot. Data are representative of three mice per group. Quantification of the intensity was normalized by actin (N = 3 per group). high blood pressure skydiving https://greatlakesoffice.com

IRF7 - an overview ScienceDirect Topics

WebSnippet: Plasmacytoid dendritic cells (pDCs) are robust producers of interferon α (IFNα) and one of the first immune cells to respond to simian immunodeficiency virus infection. To elucidate responses to early HIV-1 replication, we studied blood pDCs in 29 HIV-infected participants who initiated antiretroviral therapy during acute infection and underwent … WebNov 17, 2024 · Plasmacytoid dendritic cells (pDCs) are the key producers of type I interferons (IFNs), thus playing a central role in initiating antiviral immune response. Besides robust type I IFN production, pDCs also act as antigen presenting cells post immunogenic stimulation. Transcription factor Irf8 is indispensable for the development of both pDC … WebNov 17, 2024 · Plasmacytoid dendritic cells (pDC) sense viral RNA through toll-like receptor 7 (TLR7), form self-adhesive pDC–pDC clusters, and produce type I interferons. This cell adhesion enhances type I... high blood pressure skin crawling

Plasmacytoid dendritic cells control dengue and …

Category:IRF5, IRF8, and IRF7 in human pDCs — the good, the bad, and …

Tags:Irf7 pdc

Irf7 pdc

IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, …

WebApr 12, 2024 · After s.c. infection with CHIKV Irf3/7 double deficient mice succumb to the virus while 100% of pDC:Irf7 + mice survive the infection exhibiting no overt clinical symptoms similar to WT mice. Early control of viremia in pDC:Irf7 + mice was reduced as compared to WT but still improved as compared to Irf3/7 double deficient mice. Thus, … Web3102 CG VIP Volvera (FIAT PDC) Via Stazione 30 Bastida 27050 IT 3111 CG Warren Parts Depot 21035 Sherwood, Warren PDC - B Warren MI 48091 US 6203 CG Warren Stamping …

Irf7 pdc

Did you know?

WebContribute to zhengxj1/Seurat development by creating an account on GitHub. WebIRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the insignificant? Interferon (IFN) regulatory factors (IRFs) are transcription factors with versatile functions in the …

WebIRF7. IRF7 is associated with the detection of foreign DNA from microbes or pathogens via pattern recognition receptors such as Toll-like receptors (TLRs) and the Cytosolic DNA … WebJul 4, 2013 · Following phosphorylation, IRF7 translocates to the nucleus and initiates the transcription of type I and type III IFNs. IRF5 positively regulates the induction of pro …

WebAug 13, 2024 · IRF7 was recognized earlier as specific to plasmacytoid dendritic cells (pDC) or antigen specific cells (APCs). However, corneal endothelial cells are not professional APCs, and it is not clear... WebNov 17, 2004 · IRF7 has constitutively high expression in pDCs but not in DCs 64,65,66. Moreover, MyD88 recruits IRF7 but not IRF3 through the adaptor molecule TRAF6 (ref. 67 ).

WebOct 16, 2024 · A recent study suggested that estrogens regulate pDC IFN-I production through IRF5, which may act by enhancing IFN-α production in synergy with IRF7 . Besides the role of estrogens, X-linked genetic factors could also be involved in the sex-dependent differences in the TLR-7-mediated responses of pDCs.

WebJun 19, 2024 · To validate the Irf7 knock-in in pDC:Irf7 + mice, we analyzed IRF7 protein levels in DC subsets. pDCs were the only cell type to retain significant levels of IRF7 … high blood pressure signs eyeWebMar 29, 2024 · The role for IRF7 has been suggested not only for is critical role in regulating IFN-a production by pDCs, but also genetic association studies showing certain SNPs in IRF7 to confer enhanced risk for developing SLE. how far is milbank sd from sioux falls sdWebJul 25, 2024 · Considering that IRF7 is constitutively expressed in pDC and monocytes, whereas in most other cell types IRF7 is induced by innate IFN priming, this result suggests that IRF3 might be able to... how far is milan from vicenzaWebJun 19, 2024 · To elucidate pDC immunomodulatory functions, we developed a mouse model in which IRF7 signaling is restricted to pDC. Despite undetectable levels of IFN-I protein, pDC-restricted IRF7 signaling controlled both viruses and was sufficient to protect mice from lethal CHIKV infection. high blood pressure sildenafilWebApr 14, 2011 · IRF7 is a lymphoid-specific factor, which is constitutively expressed in the cytoplasm in B cells, pDCs and monocytes in the spleen, thymus, and peripheral blood … high blood pressure sleepyhttp://shanghaipasteur.cas.cn/zhxw/202405/t20240515_6714810.html high blood pressure skinWebMay 16, 2024 · CSFV N pro can block type I IFN production by cDC more efficiently than pDC; IRF7, which is more prominent in pDC, is less affected by this protein . Nevertheless, CSFV N pro negatively regulates IRF7, probably through interference with its turnover, reducing IFN-α release by pDC, not only after CSFV infection, but also in response to other ... high blood pressure skin problems