Cst fam134b

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August undefined, 2024

Highly specific and rigorously validated in-house, FAM134B (E8Y9R) Rabbit Monoclonal Antibody (CST #83414) is ready to ship. ... FAM134B (family with sequence similarity 134, member B), also referred to as JK-1 and RETREG1, is a cis-Golgi endoplasmic reticulum (ER) transmembrane protein that plays a role in ER homeostasis and may contribute to ... WebNational Center for Biotechnology Information

Critical roles of FAM134B in ER-phagy and diseases

Webanti-LC3B (1:200; CST, USA; #83506) and rabbit anti-FAM134B (1:100; Abcam, USA; ab151755) overnight at 4 °C. Subsequently, the neurons were incubated with dye … WebOct 4, 2016 · FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga Abhilash I. Chiramel, Jonathan D. Dougherty, Vinod Nair, Shelly J. Robertson, Sonja M. Best how to set up psk31

FAM134B Attenuates Seizure-Induced Apoptosis and …

WebAug 24, 2024 · Several ER surface receptors, including FAM134B, reticulon 3L (RTN3L), Sec62, and CCPG1, have been shown to contain conserved LC3-interacting regions (LIRs) that can act as specific autophagy receptors to allow portions of the larger ER network to be shunted to core autophagy pathways ( Khaminets et al., 2015; Fumagalli et al., 2016; … WebJul 8, 2024 · The endoplasmic reticulum (ER) autophagy receptor FAM134B contains an LIR motif that can bind to Atg8s, but whether it can differentially bind to the two … WebJun 3, 2015 · ER-bound FAM134B interacts with a protein called LC3 in phagophores through an LIR domain, leading to engulfment of ER fragments by autophagosomes. Mochida et al . 2 report that Atg39 and Atg40 ... how to set up pst

Beating the ER: novel insights into FAM134B function and …

RETREG1 (FAM134B): A new player in human diseases: 15 …

WebMay 30, 2024 · FAM134B/RETREG1 is a selective ER-phagy receptor that regulates the size and shape of the endoplasmic reticulum. The structure of its reticulon-homology domain (RHD), an element shared with other... WebPolyclonal Antibody for studying FAM134B. Cited in 3 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, FAM134B Antibody (CST #61011) is … how to set up pst files in outlookWebDec 2, 2024 · FAM134B was also called JK-1, encoding a newly identified Golgi resident protein. It has been reported participating in turnover of ER membranes, tumor inhibition, and lipid homeostasis 10 - 13. FAM134B might play a functional role in fat deposition, as it has been shown that FAM134B is a positive regulator of lipid deposition in preadipocytes … how to set up pspix on computer

"WebDec 14, 2024 · FAM134B has also been associated with different cancers, although its exact role remains elusive. We report here that the FAM134B gene encodes not one but … " - Cst fam134b

Cst fam134b

Curvature induction and membrane remodeling by FAM134B

WebMay 30, 2024 · FAM134B, the first ER-phagy receptor to be identified, contains a reticulon-homology domain (RHD). FAM134B targets ER … WebOct 28, 2024 · In contrast, FAM134B may rather act as a tumor suppressor, since FAM134B mutations have been frequently found in colorectal adenocarcinoma, and esophageal squamous cell carcinoma [41, 43, 73].

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WebJan 13, 2024 · FAM134B forms oligomers that are required for ER membrane scission and ER-phagy A. Endogenous FAM134B forms oligomers. FAM134B knockout (KO) or wild-type (WT) 293T cells were treated with 1 μM of Thapsigargin (Tg) for different time, and the cell lysates were prepared and analyzed by Western blot. WebFAM134B overexpression also ameliorated the AE-induced ultrastructural damage in neuronal mitochondria, decrease in mitochondrial membrane potential (mMP), cytochrome c (CytC) release and caspase-3 activation, while FAM134B downregulation induced the …

WebDec 31, 2024 · Department of the Treasury Internal Revenue Service Cincinnati, OH 45999-0039 Notice CP134B Tax period December 31, 2024 Notice Date January 8, 2024 … WebMay 17, 2024 · Four ER-resident proteins (FAM134B, CCPG1, SEC62, and RTN3) have been identified as ER-resident cargo receptors, which contain LC3-interacting regions. In this study, we identified an N …

WebDec 16, 2024 · The Fam134b gene, located on chromosome 5p15.1, was first identified as a regulator of the malignant phenotype and a downstream molecule of δ-catenin in esophageal squamous cell carcinoma (Tang et al., 2007). However, in colon cancer, FAM134B inhibits the migration of tumor cells (Kasem et al., 2014a, b). WebThe protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non-functional …

WebFAM134B (family with sequence similarity 134, member B), also referred to as JK-1 and RETREG1, is a cis-Golgi endoplasmic reticulum (ER) transmembrane protein that plays a role in ER homeostasis and may …

WebRespond to Notice CP134B. First, order the Account Transcripts for ALL time periods from the IRS. Then compare your deposits with the Account Transcripts. If you use a payroll … how to set up pst fileWebFeb 19, 2024 · FAM134B was the first and so far the best characterized ER-phagy receptor (Khaminets et al, 2015). FAM134B is an intramembrane ER-resident protein that contains a LIR domain and a reticulon homology … nothing phone 1 hypeWebApr 11, 2024 · Crucially, to confirm that endogenous FAM134B flux follows a similar trend to the overexpressed reporter, we looked at FAM134B localization in PDAC cells upon BafA1 treatment (Figure 4D). Indeed, FAM134B puncta accumulation after autophagy block indicates high basal turnover rate of the receptor in line with our observation with the … how to set up pst files in outlook 365WebFeb 19, 2024 · FAM134B was the first and so far the best characterized ER-phagy receptor (Khaminets et al, 2015). FAM134B is an intramembrane ER-resident protein that contains a LIR domain and a reticulon homology domain (RHD), which consists of two membrane-embedded hydrophobic regions bridged by a flexible cytoplasmic linker ... nothing phone 1 good or badWebOct 13, 2015 · Mutant FAM134B proteins that cause sensory neuropathy in humans (HSAN2B; 613115) are unable to act as ER-phagy receptors. Consistently, disruption of Fam134b in mice causes expansion of the ER, inhibits ER turnover, sensitizes cells to stress-induced apoptotic cell death, and leads to degeneration of sensory neurons. nothing phone 1 in dubaiWebDec 14, 2024 · FAM134B (also called RETREG1) is a critical gene for neuronal survival. FAM134B loss-of-function mutations cause hereditary sensory and autonomic neuropathy type II, and its knockdown results in structural alterations of the cis -Golgi compartment, inducing apoptosis in some primary dorsal root ganglion neurons ( 25 ). nothing phone 1 in uaeWebNov 16, 2024 · FAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal … how to set up pst in outlook